Clear Cell Carcinoma of the Ovary in a 24-Year-Old Female Associated with Endometriosis

Clear cell carcinoma (CCC) represents 2-10% of all epithelial ovarian cancers. 24-50% of the patients are known to have associated pelvic endometriosis. Women typically present between the ages of 40 and 70 with the peak incidence at age 52. CCC is rarely described in young females with youngest reported age being 23 years [1]. Risk factors for ovarian cancers include family history, age and nulliparity. The condition is classically associated with dysmenorrhoea, deep dyspareunia and infertility. Endometriosis, a common benign gynaecologic condition, has been reported in association with certain epithelial ovarian tumours. According to a previous report, the rank order of the prevalence of endometriosis in each histologic type is clear cell (39.2%) > endometrioid (21.2%) > serous (3.3%) > mucinous type (3.0%) [2]. Scully and Barlow in 1967 established the close association between CCC, endometrioid carcinoma of the ovary and endometriosis [3]. We present a case of CCC associated with endometriosis in a 24-year-old young female with immunohistochemistry (IHC).